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What is Amantadine?
Amantadine has an indirect agonistic effect on striaty dopamine receptors. Increases the extracellular concentration of dopamine through both the intensification of its production and the blockade of dopamine reuptake by presynaptic neurons. At therapeutic concentrations, amantadine slows down the production of acetylcholine and, thus, has an anticholinergic effect.
Indications for use
Parkinson’s disease (muscle rigidity, tremor, hypo-or akinesia).
Extrapyramidal disorders caused by the administration of antipsychotics or other drugs (dyskinesia, akathisia and parkinsonism).
Neuralgia for Herpes Zoster (Herpes Zoster).
The use of all forms of lamisil is contraindicated in case of hypersensitivity to terbinafine or to auxiliary components of the drug.
Hypersensitivity to any of the components of the drug; severe congestive heart failure (class IV on the scale of the New York Heart Association), cardiomyopathy, myocarditis, atrioventricular blockades of II and III degree, bradycardia with a heart rate of less than 55 beats / min, prolongation of the QT interval of more than 420 ms, ventricular arrhythmia (including including ventricular flutter), pregnancy and breastfeeding period, low blood levels of potassium and magnesium, simultaneous use with drugs that extend the QT interval, severe renal failure (creatinine clearance less than 10 ml / min), children (up to 18 years), hereditary galactose deficiency, lactase deficiency, glucose-galactose malabsorption, phenylketonuria, sucrose-isomalt insufficiency, hereditary fructose insufficiency, psychosis (in history).
Prostatic hyperplasia, narrow-angle glaucoma, renal failure of varying severity (there is a risk of drug cumulation), agitation, delirium, depression of the central nervous system, exogenous psychosis (including in history), joint reception with memanthina, triamterene / hydrochlorothiazide.
How to use? (Dosage)
Inside, after eating with a small amount of liquid, preferably in the first half of the day. The first 3 days – 1 tablet per day, then increase the dose to 2 tablets per day, with a further dose increase of 1 tablet per week. The usual effective dose is 1 to 3 tablets twice a day. The maximum daily dose is 600 mg. In the case of combined treatment, it is necessary to determine the dose individually. The last dose is recommended to be taken in the afternoon not later than 16-00.
From the nervous system, sensory organs and psyche: Often: insomnia, psychomotor agitation, paranoid exogenous psychosis, accompanied by visual hallucinations (in susceptible elderly patients), dizziness, visual acuity. Very rarely: epileptic seizures (usually after a dose that exceeds the recommended one), peripheral neuropathy, temporary loss of vision, myoclonia.
Since the cardiovascular system: Very rare: arrhythmia, tachycardia, ventricular fibrillation, prolongation of the QT interval, development or worsening of heart failure, orthostatic hypotension. Often: marble skin syndrome combined with swelling of the ankles and lower legs.
On the part of the gastrointestinal tract: Often: nausea, dry mouth.
Other: Often: urinary retention in patients with prostate adenoma. Very rarely: allergic skin reactions, photosensitivity, leukopenia, thrombocytopenia, swelling of the cornea of the eye, reversible after stopping the drug.