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What is Colchicine?
Colchicine – a remedy for gout.
Colchicine is able to reduce the migration of leukocytes into the inflammatory focus and inhibit the phagocytosis of uric acid salt microcrystals. Partially or completely inhibits cell division in the metaphase and anaphase stages, has antimyotic action, stops neutrophil degranulation. Interferes with the development of amyloidosis, reduces the formation of amyloid fibrils.
Indications for use
- Colchicine according to the instructions prescribed for:
- gout for the prevention or prevention of acute attacks;
- scleroderma, chondrocalcinosis, gouty arthritis;
- inflammatory diseases in otolaryngology and dentistry, some forms of phlebitis;
- familial Mediterranean fever, amyloidosis.
Colchicine According to the instructions, Colchicine is contraindicated when:
- acute hepatic or renal failure; neutropenia;
- severe dysfunctions of the bone marrow, gastrointestinal tract, cardiovascular system;
- purulent infections;
- old age;
- colchicine hypersensitivity.
Treatment with colchicine or its analogs is carried out under careful clinical and hematological control. With the manifestation of side effects from the gastrointestinal tract, it is necessary to reduce the dosage or completely cancel the drug.
In the case of a decrease in platelets below 100 thousand / μl and leukocytes below 3 thousand / μl, you should stop taking Colchicine or its analogues.
How to use?
According to the instructions, colchicine is taken orally. In the presence of an inflammatory process and an acute attack of gout, the dosage is:
- on the first day – one tablet three times a day, on the second and third days – one tablet twice a day, on the fourth and the following days – one tablet once a day (preferably in the evening).
- According to another scheme, one pill is taken, and after that, with an interval of one to two hours, taken another half or a full pill until the acute pain disappears.
- For prophylactic purposes, the dosage of Colchicine according to the instructions is one tablet once a day (preferably in the evening) for three months.
- The maximum dosage is 8 tablets per day. When amyloidosis take one to three tablets per day. The duration of treatment is at least five years.
According to reviews, colchicine can cause such side effects:
- Central nervous system: peripheral neuritis, depression, neuropathy.
- Digestive system: nausea, abdominal pain, vomiting, loss of appetite, abnormal liver function, diarrhea, malabsorption syndrome (manifested in a lack of vitamin B12).
- Hematopoietic system: myelosuppression – aplastic anemia, neutropenia, agranulocytosis, leukopenia. With prolonged use, reviews of colchicine indicate a possible manifestation of thrombocytopenia.
- Allergic reactions: core-like rash, urticaria.
- Others: temporary alopecia, renal dysfunction, myopathy, azoospermia.
Overdose of Colchicine according to reviews causes the following symptoms: severe diarrhea, abdominal pain, vomiting, nausea, pain in the oral cavity, burning skin, hemorrhagic gastroenteritis, severe dehydration and a decrease in blood pressure (up to hypovolemic shock), hematuria, convulsions, ST segment elevation ECG, oliguria, reduction in myocardial contractility, depression of respiratory function, ascending paralysis.