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Nexium decreases the amount of acid produced in the stomach. It is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. It is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid). It may also be given to prevent gastric ulcer caused by infection with helicobacter pylori (H. pylori) or by the use of nonsteroidal anti-inflammatory drugs (NSAIDs).
Active Ingredient: Esomeprazole
Availability: In Stock (31 Packages)
|Product name||Per Pill||Savings (only today)||Per Pack|
|60 pills||$0.81||$48.74||ADD TO CART|
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|360 pills||$0.50||$111.11||$292.41 $181.30||ADD TO CART|
What is Nexium?
Nexium is a drug that reduces the production of hydrochloric acid by the glands of the stomach. Due to the inhibition of the secretory activity of the glands, Nexium reduces the acidity of gastric juice and is used in the complex treatment of various conditions associated with excessive secretion of hydrochloric acid (for example, gastroesophageal reflux disease, gastric ulcer or duodenal ulcer, impaired mucosal structure under the influence of drugs from the NSAID group eradication of Helicobacter pylori, etc.).
Indication for use
- Treatment of erosive reflux esophagitis;
- Long-term maintenance treatment in patients after healing of erosive reflux esophagitis (in order to prevent recurrence);
- Symptomatic treatment of gastroesophageal reflux disease;
- Therapy of duodenal ulcer associated with Helicobacter pylori (Helicobacter pylori);
- Prevention of relapse of peptic ulcer associated with Helicobacter pylori;
- Long-term acid suppressing treatment after peptic ulcer bleeding (after intravenous use of drugs that reduce the secretion of the gastric glands, to prevent relapse)
- Healing of gastric ulcers associated with taking nonsteroidal anti-inflammatory drugs;
- Prevention of gastric and duodenal ulcers associated with taking nonsteroidal anti-inflammatory drugs in at-risk patients;
- Zollinger-Ellison syndrome or other conditions that are characterized by pathological hypersecretion (including idiopathic hypersecretion).
Children 1-18 years old Nexium is prescribed for gastroesophageal reflux disease on the background of erosive reflux esophagitis and / or severe symptoms of reflux disease.
For adults, the drug should be used if the following indications:
- Treatment of gastroesophageal reflux disease in patients with esophagitis and / or severe signs of reflux disease;
- Healing of peptic ulcers associated with taking nonsteroidal anti-inflammatory drugs;
- Prevention of peptic ulcers associated with taking nonsteroidal anti-inflammatory drugs in at-risk patients;
- Prevention of recurrent bleeding from peptic ulcers after endoscopic hemostasis.
- Glucose-galactose malabsorption, hereditary fructose intolerance, sucrose-isomaltase deficiency (tablets, granules and pellets);
- Concurrent use with atazanavir and nelfinavir;
- Hypersensitivity to the components of the drug, as well as to substituted benzimidazoles.
According to the instructions, Nexium should be used with caution in patients with severe renal failure.
Depending on the dosage form, Nexium is contraindicated in children in the following cases:
- Tablets: age up to 12 years – all indications; age 12-18 years – all indications, except for gastroesophageal reflux disease;
- If any warning signs appear (in the form of a significant sudden loss of body weight, repeated vomiting, dysphagia, vomiting with blood admixture), as well as in the presence of gastric ulcer (or suspicion of it), the presence of malignant tumors should be excluded, smoothing the symptoms that will delay the diagnosis.
- When conducting long-term treatment (especially longer than a year), patients must undergo regular medical supervision.
- In cases of use of the drug “as needed” should inform the doctor about the appearance of atypical symptoms.
- During therapy, care should be taken when driving, which is associated with the likelihood of such side effects as dizziness, drowsiness and blurred vision.
How to use?
Tablets should be swallowed whole, without chewing them in your mouth and drinking plenty of water (at least half a glass). If it is impossible to swallow the pill whole, it can be placed in half a glass of non-carbonated water and wait for disintegration into granules. These granules should be shaken to obtain a suspension and drink it immediately or within half an hour. You can not crush and bite the granules.
For gastroesophageal reflux disease with Nexium esophagitis, 40 mg should be taken 1 time per day for 4 weeks. If, after a course of therapy, no complete cure has taken place or the symptoms of the disease have persisted, then Nexium should be taken 40 mg once a day for 4 more weeks without a break.
For maintenance therapy after the cure of gastroesophageal reflux disease with erosive esophagitis in order to prevent relapse, you must take Nexium 20 mg 1 time a day for several months.
When gastroesophageal reflux disease without esophagitis Nexium should be taken at a dose of 20 mg once a day for 4 weeks. If, after the course of therapy, the symptoms of gastroesophageal reflux disease have not disappeared, the drug should be continued in the same dosage for another 4 weeks without any interruption.
For the treatment and prevention of recurrence of gastric ulcer or duodenal ulcer associated with Helicobacter pylori, Nexium must be taken 20 mg twice a day for a week. In the treatment of peptic ulcer, Nexium is used in combination therapy, and in prophylactic use – in isolation.
To prevent recurrence in people who have suffered bleeding from an ulcer, Nexium for the implementation of acid suppression therapy is first administered intravenously 40 mg once a day for 2 to 3 weeks, then taken orally in the form of tablets 40 mg once a day for 4 weeks.
For the healing of gastric ulcers triggered by prolonged use of drugs from the group of NSAIDs, Nexium should be taken in 20 mg or 40 mg 1 time per day for 4-8 weeks. For the prevention of gastric or duodenal ulcers against the background of taking NSAIDs, Nexium should take 20 mg or 40 mg 1 time per day throughout the entire period of using NSAIDs.
For the treatment of various diseases associated with pathological excessive production of hydrochloric acid (Zollinger-Ellison syndrome, etc.), Nexium begins to take 40 mg twice a day. If this dosage did not lead to the elimination of symptoms, then it should be increased to the value at which the human condition returns to normal. The maximum allowable dosage of Nexium is 120 mg twice a day.
Reducing the dosage of Nexium in the elderly and those suffering from renal failure is not required. In severe liver failure, the maximum daily dosage of Nexium is 20 mg, while in moderate and mild it is the same as for all other people. Children under 12 years old Nexium tablets are contraindicated, and adolescents from the age of 13 take the drug in adult dosages.
- Nervous system: often – headache; infrequently – paresthesias, dizziness, drowsiness; rarely – a violation of taste;
- Musculoskeletal system: rarely – myalgia, arthralgia; very rarely, muscle weakness;
- Hematopoietic system: rarely – leukopenia, thrombocytopenia; very rarely – pancytopenia, agranulocytosis;
- Urinary system: very rarely – interstitial nephritis;
- Respiratory system: rarely – bronchospasm;
- Gastrointestinal system: often – constipation, abdominal pain, diarrhea, flatulence, vomiting / nausea; infrequently – dry mouth; rarely – candidiasis of the gastrointestinal tract, stomatitis; very rarely – microscopic colitis confirmed by histological studies;
- Skin and subcutaneous tissue: infrequently – dermatitis, rash, itching, urticaria; rarely – photosensitivity, alopecia; very rarely – toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme;
- Mammary glands and reproductive system: very rarely – gynecomastia;
- Liver and biliary tract: infrequently – increased activity of liver enzymes; rarely, hepatitis (with or without jaundice); very rarely – liver failure, encephalopathy in patients with liver disease;
- Organ of vision: rarely – blurred vision;
- Mental disorders: infrequently – insomnia; rarely – agitation, depression, confusion; very rarely – aggressive behavior, hallucinations;
- Metabolism: rarely – hyponatremia; very rarely – hypomagnesaemia, hypocalcemia (associated with severe hypomagnesiemia), hypokalemia (caused by hypomagnesiemia);
- Allergic reactions: rarely – hypersensitivity reactions (in the form of fever, angioedema, anaphylactic reactions / anaphylactic shock);
- Other: infrequent – peripheral edema; rarely – sweating, malaise.