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Prednisolone is used for treating allergies, arthritis, breathing problems (e.g., asthma), certain blood disorders, collagen diseases (e.g., lupus), certain eye diseases (e.g., keratitis), cancer (e.g., leukemia), endocrine problems (e.g., adrenocortical insufficiency), intestinal problems (e.g., ulcerative colitis), swelling due to certain conditions, or skin conditions (e.g., psoriasis).
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What is Prednisolone?

Phenergan (promethazine) refers to a group of drugs called phenothiazines. It works by changing the actions of chemicals in your brain. Promethazine also acts as an antihistamine. It blocks the effects of the natural chemical histamine in your body.

Phenergan is used to treat symptoms of allergies such as itching, runny nose, sneezing, itching or watery eyes, urticaria and skin itching.

Phenergan also prevents motion sickness and treats nausea, vomiting or pain after surgery. It is also used as a sedative or sleep aid.


Prednisolone is used for emergency therapy in conditions that require a rapid increase in the concentration of GCS in the body:

  • shock states (burn, traumatic, operative, toxic, cardiogenic) – with the ineffectiveness of vasoconstrictor agents, plasma replacement drugs and other symptomatic therapy;
  • allergic reactions (acute severe forms), blood transfusion shock, anaphylactic shock, anaphylactoid reactions;
  • cerebral edema (including on the background of a brain tumor or associated with surgery, radiation therapy or head injury);
  • bronchial asthma (severe), asthmatic status;
  • systemic connective tissue diseases (systemic lupus erythematosus, rheumatoid arthritis);
  • acute adrenal insufficiency;
  • thyrotoxic crisis;
  • acute hepatitis, hepatic coma;
  • reduction of inflammation and prevention of cicatricial contractions (in case of poisoning with cauterizing liquids).


The dose of Prednisolone and the duration of treatment is determined by the doctor individually, depending on the evidence and the severity of the disease.

Prednisolone is administered in / in (drip or jet) or in / m. In / in the drug is usually administered first jet, then drip.

With acute adrenal insufficiency a single dose of 100-200 mg for 3-16 days.

In case of bronchial asthma, the drug is administered, depending on the severity of the disease and the effectiveness of complex treatment, from 75 to 675 mg per treatment course, from 3 to 16 days; in severe cases, the dose may be increased to 1,400 mg per course of treatment and more with a gradual decrease in dose.

In asthmatic status, Prednisolone is administered at a dose of 500-1200 mg / day, followed by reduction to 300 mg / day and switching to maintenance doses.

In thyrotoxic crisis, 100 mg of the drug is administered in a daily dose of 200-300 mg; if necessary, the daily dose may be increased to 1000 mg. The duration of administration depends on the therapeutic effect, usually up to 6 days.

In shock, resistant to standard therapy, Prednisolone at the beginning of therapy is usually administered injectable, and then go on drip. If within 10-20 minutes the blood pressure does not increase, repeat the injection of the drug. After withdrawal from shock, the drip continues to stabilize blood pressure. A single dose is 50-150 mg (in severe cases, up to 400 mg). The drug is re-administered after 3-4 hours. The daily dose may be 300-1200 mg (with subsequent reduction of the dose).

In case of acute renal and hepatic failure (in case of acute poisoning, in the postoperative and postpartum periods, etc.), Prednisolone is administered at 25-75 mg / day; in the presence of indications the daily dose may be increased to 300-1500 mg / day and higher.

In rheumatoid arthritis and systemic lupus erythematosus, Prednisolone is administered in addition to the systemic drug in a dose of 75-125 mg / day for no more than 7-10 days.

In acute hepatitis, Prednisolone is administered at 75-100 mg / day for 7-10 days.

In case of poisoning with cauterizing liquids with burns of the digestive tract and upper respiratory tract, Prednisolone is prescribed in a dose of 75-400 mg / day for 3-18 days.

If it is impossible to / in the introduction of Prednisolone administered in / m in the same doses. After stopping the acute condition, prednisolone is administered orally in tablets, followed by a gradual decrease in dose.

With long-term use of the drug, the daily dose should be reduced gradually. Long-term therapy should not be stopped suddenly!

Side effects

The frequency of development and severity of side effects depends on the duration of use, the magnitude of the dose used and the ability to comply with the circadian rhythm of prednisolone.

With the use of prednisolone may be noted:

From endocrine system: reduction of glucose tolerance, steroid diabetes or a manifestation of latent diabetes mellitus, adrenal suppression, Cushing’s syndrome (moon face, obesity, pituitary type, hirsutism, increased blood pressure, dysmenorrhea, amenorrhea, muscle weakness, striae) , delayed sexual development in children.

On the part of the digestive system: nausea, vomiting, pancreatitis, steroid gastric and duodenal ulcer, erosive esophagitis, gastrointestinal bleeding and perforation of the gastrointestinal tract wall, increased or decreased appetite, indigestion, flatulence, hiccups. In rare cases – increased activity of hepatic transaminases and alkaline phosphatase.

Since the cardiovascular system: arrhythmias, bradycardia (up to cardiac arrest); development (in predisposed patients) or increased severity of heart failure, changes in the electrocardiogram, characteristic of hypokalemia, increased blood pressure, hypercoagulation, thrombosis. In patients with acute and subacute myocardial infarction – the spread of necrosis, slowing the formation of scar tissue, which can lead to rupture of the heart muscle.

Nervous system disorders: delirium, disorientation, euphoria, hallucinations, manic-depressive psychosis, depression, paranoia, increased intracranial pressure, nervousness or anxiety, insomnia, dizziness, vertigo, pseudotumor of the cerebellum, headache, convulsions.

On the part of the senses: posterior subcapsular cataract, increased intraocular pressure with possible damage to the optic nerve, a tendency to develop secondary bacterial, fungal or viral infections of the eye, trophic changes of the cornea, exophthalmos, sudden loss of vision (with parenteral administration in the head, neck, nasal shells, scalp possible deposition of crystals of the drug in the vessels of the eye).

On the part of the metabolism: increased excretion of calcium, hypocalcemia, increased body weight, a negative nitrogen balance (increased protein breakdown), increased sweating.

Conditioned mineralocorticoid activity: fluid and sodium retention (peripheral edema), hypernatremia, hypokalemic syndrome (hypokalemia, arrhythmia, myalgia or muscle spasm, unusual weakness and fatigue).

On the part of the musculoskeletal system: slower growth and processes of ossification in children (premature closure of the epiphyseal growth zones), osteoporosis (very rarely – pathological bone fractures, aseptic necrosis of the head of the humerus and femur), muscle tendon rupture, steroid myopathy, muscle mass reduction (atrophy).

On the part of the skin and mucous membranes: delayed wound healing, petechiae, ecchymosis, thinning of the skin, hyper- or hypopigmentation, steroid acne, stretch marks, a tendency to the development of pyoderma and candidiasis.

Allergic reactions: skin rash, itching, anaphylactic shock, local allergic reactions.

Local with parenteral administration: burning, numbness, pain, tingling at the injection site, infection at the injection site, rarely – necrosis of surrounding tissues, scarring at the injection site; atrophy of the skin and subcutaneous tissue when i / m administration (especially the introduction into the deltoid muscle).

Others: the development or exacerbation of infections (jointly used immunosuppressants and vaccination contribute to the occurrence of this side effect), leukocyturia, “withdrawal” syndrome.

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