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What is Promethazine?
The blocker of histamine H1 receptors, has a high antihistamine activity and a pronounced blocking effect on the central nervous system. Causes a sedative effect, has anti-emetic effect. It also has a pronounced adrenoblokiruyuschee, moderate peripheral and central holinoblokiruyuschee effect. The effect begins to develop 20 minutes after administration and lasts for 6 hours, sometimes up to 12 hours.
Indications for use
Allergic diseases and reactions: rash, itching, eczema, drug rash, serum sickness, angioedema, hay fever, anaphylactic shock, bronchoobstructive syndrome (as part of complex therapy).
Skin diseases (including eczema, neurodermatitis, diathesis, contact dermatitis and toxicoderma).
In anesthesiology: as a sedative before and after surgery, as an adjuvant in conjunction with analgesics; for the prevention and treatment of nausea and vomiting during anesthesia and surgical interventions; with artificial hibernation.
As part of a combination therapy or as an additional tool: kinetoz, migraine, sleep disorders, states of arousal; stomach ulcer and duodenal ulcer.
In pediatrics: changes in the skin and mucous membranes in infants on the background of exudative diathesis, eczema, asthmatic bronchitis, false croup, various types of allergic, serum sickness.
When ingested for adults, the daily dose is 75-100 mg.
Maximum doses: when taken orally, one-time – 75 mg, daily – 500 mg; with intramuscular administration a single 50 mg, daily 250 mg.
In / in used in the composition of lytic mixtures.
For children aged 1 to 2 years, by mouth – 5-10 mg 1-2 times / day; from 2 to 5 years – 5-10 mg 1-3 times / day; from 5 to 10 years – 5-15 mg 1-3 times / day; older than 10 years and adolescents 5–20 mg 1–3 times / day. When i / m injection dose is 0.5-1 mg / kg, the frequency of administration – 3-5 times a day. In case of emergency (asthmatic status, false croup), the dose may be increased to 1-2 mg / kg. With the on / in the introduction (usually as part of a lytic cocktail), the dose is 1/3 of the dose for the / m injection.
On the part of the digestive system: moderately pronounced numbness of the oral mucosa, dry mouth, nausea, constipation, diarrhea, discomfort; rarely jaundice.
On the part of the central nervous system and peripheral nervous system: drowsiness, dizziness, anxiety, lethargy, fatigue, impaired coordination of movements, blurred vision; rarely – tinnitus, euphoria, nervousness, insomnia, convulsions, oculogy crisis, catatonic status, hysteria, psychomotor agitation, extrapyramidal disorders, headache, nystagmus.
Since the cardiovascular system: rarely – tachycardia, bradycardia, palpitation, syncope, hypotension (with a / in the introduction), arrhythmias.
Dermatological reactions: rarely – contact dermatitis, photosensitivity, urticaria.
From the hematopoietic system: rarely – leukopenia, agranulocytosis, aplastic anemia, thrombocytopenic purpura.
Allergic reactions: rarely – exanthema, urticaria, angioedema, anaphylactic reactions.
Other: rarely – irregular breathing, urinary retention.
Local reactions: with intramuscular injection painful infiltrates may occur.
Promethazine is contraindicated for use in the first trimester of pregnancy. If it is necessary to conduct therapy according to clinical indications in the third trimester of pregnancy, promethazine is used in minimal maintenance doses, reducing them by the end of the term to prevent the development of drowsiness or psychomotor agitation in newborns.
If necessary, the use of promethazine during lactation should decide on the termination of breastfeeding.
Contraindicated in severe violations of the liver.
Contraindicated in early childhood up to 2 months.
Use with caution in children with acute or chronic respiratory diseases, since promethazine suppresses the cough reflex.
Not recommended for use in children for the relief of occasional vomiting of unspecified origin.