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Buy Zantac online without a doctor's prescription

zantac online
Zantac is prescribed for treatment and prevention of ulcers in the stomach and intestines, it works decreasing amount of acid in the stomach.
Active Ingredient: Ranitidine
Availability: In Stock (31 Packages)
Zantac 300mg
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Zantac 150mg
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What is Zantac?

Zantac is an anti-ulcer agent, histamine H2 receptor blocker.

Ranitidine is an active substance of Zantac, is a blocker of histamine H2 receptors. It helps reduce basal and stimulated food load, irritation of baroreceptors, gastrin, histamine and other biogenic stimulators of hydrochloric acid secretion.

Indication for use

  • Duodenal ulcer associated with Helicobacter pylori infection;
  • Duodenal ulcer and benign expressions of the stomach, including those that occurred while taking nonsteroidal anti-inflammatory drugs (NSAIDs);
  • Gastroesophageal reflux disease, including the relief of pain;
  • Postoperative ulcers;
  • Reflux esophagitis;
  • Chronic episodic dyspepsia, occurring with chest or epigastric pain (not related to the above), which interfere with sleep or are associated with food intake;
  • Zollinger-Ellison syndrome;
  • Prevention of stressful stomach ulcers in patients with serious illnesses;
  • Prevention of duodenal ulcers with the use of NSAIDs (including acetylsalicylic acid), especially with a history of ulcer disease;
  • Prevention of recurrent bleeding from peptic ulcers;
  • Prevention of aspiration of acidic contents of the stomach during general anesthesia (Mendelssohn’s syndrome).

Contraindications

  • Acute porphyria (including history);
  • Period of pregnancy and breastfeeding;
  • Age up to 12 years;
  • Hypersensitivity to the drug.

It should be used with caution in patients with hepatic and renal insufficiency, cirrhosis of the liver with a history of portosystemic encephalopathy.

Special instructions

  • The use of Zantac is able to hide the symptoms of carcinoma of the stomach, therefore, patients with a stomach ulcer or new signs of dyspepsia in the elderly and middle age are advised to rule out the possibility of malignancy before starting treatment.
  • Because of the risk of ricochet syndrome, Zantac should be discontinued, gradually reducing the dose.
  • Simultaneous reception of ranitidine with NSAIDs must be accompanied by regular monitoring of patients, especially in old age and with a peptic ulcer in history.
  • Effervescent tablets should be taken with caution in patients with sodium restriction, with phenylketonuria.
  • It is not recommended to use Zantac before diagnosing skin samples to detect an allergic skin reaction of the immediate type.
  • Patients with severe renal insufficiency need to be adjusted dosing regimen.
  • An increase in the level of hepatic transaminases can be observed when parenterally administered with high doses of the drug for more than 5 days.
  • The use of Zantac can cause an increase in glutamate transpeptidase activity or cause a false-positive reaction when testing for the presence of protein in the urine.
  • In tobacco-dependent patients, the effectiveness of Zantac therapy is reduced.
  • During the period of treatment the patient should not eat foods, drinks and medicines that cause irritation of the gastric mucosa.
  • During the use of Zantac, the patient cannot engage in potentially hazardous activities that require concentration of attention and high speed of psychomotor reactions.
  • Ranitidine crosses the placenta and is excreted in breast milk.
  • Pregnancy is a contraindication to taking the drug. Zantac can only be prescribed if the doctor assesses the expected benefit to the mother above the possible harm to the fetus.
  • During lactation, Zantac is contraindicated.
  • Patients under the age of 12 are not assigned to Zantac.
  • In renal failure, Zantac is prescribed with caution.
  • In patients with hepatic insufficiency and in patients with cirrhosis of the liver with a history of portosystemic encephalopathy, caution is required during therapy.
  • Elderly patients with the combined use of Zantac with NSAIDs require regular monitoring.

How to use?

The recommended dosing of Zantac for adult patients:

  • Exacerbation of benign gastric and duodenal ulcers: 150 mg 2 times a day (morning and evening) or 300 mg 1 time per day (overnight) for 4 weeks. In the absence of complete scarring of the ulcer, treatment should be extended for another 4 weeks. For the treatment of duodenal ulcers, a dose of 300 mg 2 times a day is more effective (an increase in dose does not affect the incidence of undesirable effects);
  • Long-term prevention of recurrence of gastric and duodenal ulcers: 150 mg 1 time per day (at night), for smoking patients, the dose is increased to 300 mg 1 time per day;
  • Ulcers associated with taking NSAIDs: 150 mg 2 times a day or 300 mg 1 time a day (at night). The course of treatment is 8-12 weeks;
  • Prevention of ulcers with the use of NSAIDs: 150 mg 2 times a day during the entire period of taking NSAIDs;
  • Duodenal ulcer associated with Helicobacter pylori: 150 mg 2 times a day or 300 mg 1 time a day in combination with 750 mg amoxicillin 3 times a day and 500 mg metronidazole 3 times a day. The course of treatment is 2 weeks; in the next 2 weeks, Zantacom monotherapy;
  • Postoperative ulcers: 150 mg 2 times a day, the duration of therapy is 4 weeks. In the absence of a clinical effect, the treatment is extended for another 4 weeks;
  • Gastroesophageal reflux disease: 150 mg: in acute form – 2 times a day (or 1 time per day (at night) in a dose of 300 mg), the course of treatment is 8-12 weeks; with severe and moderate reflux esophagitis – 4 times a day with a duration of therapy of 12 weeks; for relief of pain, 2 times a day for 2-4 weeks; for prophylaxis – 2 times a day;
  • Zollinger-Ellison syndrome: initial dose – 150 mg 3 times a day, if necessary, you can increase the daily dose to 6000 mg;
  • Chronic episodic dyspepsia: 150 mg 2 times a day, the course of treatment is 6 weeks. In the absence of a clinical effect or deterioration of the condition, an additional examination is necessary;
  • Prevention of recurrent bleeding from peptic ulcers and bleeding stress ulcers in critically ill patients: after transferring the patient to an oral meal, parenteral therapy is replaced with the intake of Zantac by 150 mg 2 times a day;
  • Prevention of Mendelssohn’s syndrome: 150 mg on the eve (in the evening) and 2 hours before general anesthesia, parenteral administration is possible; during labor – 150 mg every 6 hours (if necessary, general anesthesia shows the simultaneous use of Zantac and water-soluble antacids (sodium citrate).

In peptic ulcers in children, Zantac is prescribed taking into account the weight of the child at a dose of 2-4 mg per 1 kg 2 times a day, but not more than 300 mg per day.

In severe renal insufficiency (creatinine clearance (CC) less than 50 ml / min), the plasma concentration of ranitidine increases, so the dose should be 150 mg 1 time per day.

When a patient is on long-term hemodialysis or ambulatory peritoneal dialysis, Zantac is prescribed immediately after the end of the session at a dose of 150 mg

Side effects

  • Cardiovascular system: arrhythmia, lowering blood pressure (BP), bradycardia, atrioventricular (AV) block; rarely – vasculitis;
  • Digestive system: dry mouth, nausea, vomiting, abdominal pain, constipation, reversible transient changes in liver function tests; in some cases, the development of usually reversible, cholestatic, hepatocellular or mixed hepatitis, with or without jaundice; rarely, acute pancreatitis, diarrhea;
  • Blood system: thrombocytopenia, leukopenia; rarely, pancytopenia, agranulocytosis; sometimes – immune hemolytic anemia, aplasia and hypoplasia of the bone marrow;
  • Musculoskeletal system: rarely – myalgia, arthralgia;
  • Nervous system: increased fatigue, headache (sometimes severe), drowsiness, dizziness; rarely – tinnitus, irritability, blurred vision, involuntary movements, reversible motor disorders of an involuntary nature; more often in elderly and seriously ill patients – hallucinations, confusion, depression;
  • Dermatological reactions: alopecia;
  • Endocrine system: gynecomastia, hyperprolactinemia, decreased libido, amenorrhea; rarely, swelling or discomfort in the male glands, reversible impotence;
  • Allergic reactions: urticaria, skin rash, bronchospasm, erythema multiforme, angioedema, anaphylactic shock, fever, arterial hypotension, chest pain.
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